The Strengths and Challenges of Conventional Short-Term Genetic Toxicity Assays

The field of toxicology is moving forward rapidly, and the trend is toward non-animal testing. In terms of genetic toxicity testing, there are many accepted OECD test guidelines reliant on in vivo animal models. In the interest of providing a complete picture of the methods available for both animal-derived and non-animal genetic toxicity testing, Part I in the series discusses the existing short-term accepted test methodologies, while Part II examines available New Approach Methodologies (NAMs). The advantages and disadvantages of the current methodologies are discussed here, while those of new methodologies and the current regulatory landscape relative to them are reserved for discussion in Part II.