Isolation and Partial Characterization of an Antiviral Proteolytic Fraction from the Venom of

Borkow, G.; Marco, D.; Ovadia, M.

Isolation and Partial Characterization of an Antiviral Proteolytic Fraction from the Venom of Echis Carinatus Sochureki

G. Borkow^{1, *}, D. Marco², M. Ovadia²

¹ Cupron Inc. Hameyasdim 44, Gibton 76910, Israel, and

² Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel

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Identifiers and Pagination:

Year: 2008
Volume: 1
First Page: 21
Last Page: 26
Publisher ID: TOBIOJ-1-21
DOI: 10.2174/1874196700801010021

Article History:

Received Date: 06/03/2008
Revision Received Date: 07/05/2008
Acceptance Date: 02/06/2008
Electronic publication date: 08/8/2008
Collection year: 2008

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© 2008 Borkow et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Cupron Inc. Chemtex, P.O. Box No. 23311, Jerusalem 91233, Israel; Tel: 972-8-546-611287; Fax: 972-8-9491254; E-mail: gadi@cupron.com

The venom of the viper Echis carinatus sochureki suppresses the hemolytic activity of Sendai virus on human erythrocytes, when pre-incubated with the virions prior to their binding to cells. A fraction (C1), with an IC₅₀ of 1.25 􀀁g/ml, was isolated from the venom. Fraction C1 possesses strong azocollase, azocaseinase and gelatinase activity. The proteolytic and anti-hemolytic potency of C1 depends on the period and temperature of incubation. Its antiviral activity is inhibited by Sodium-EDTA but not by PMSF. SDS PAGE of Sendai virus incubated with fraction C1 shows disappearance of several of the virion high molecular weight bands. We suggest that inhibition of the hemolytic activity of the virions is probably a result of the cleavage of viral surface proteins, such as the hemagglutinin-neuraminidase glycoprotein found on the virion envelope that mediates the absorption of the virus to cells.

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RESEARCH ARTICLE

Isolation and Partial Characterization of an Antiviral Proteolytic Fraction from the Venom of Echis Carinatus Sochureki

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