Aims and Scope

The Open Biology Journal is an open access online journal, which publishes research, review/mini-review and letter articles and guest edited single topic issues, reviews and letters in all areas of biology and at the interface of related disciplines. The core disciplines in biology that are published in the journal are the following: Cell & Developmental Biology; Genetics & Genomics; Molecular Biology; Structural Biology; Bioinformatics; Systems Biology; Immunology; Biochemistry; Ecology; Zoology; Ornithology; Entomology; Marine & aquatic Biology; Plant Biology; Bioethics; Behavioural science ; Microbiology; Reproductive Biology; Glycobiology; Macromolecules; Proteins & Peptides; Theoretical & Mathematical Biology; Evolutionary Biology; Techniques in Biology; Biotechnology, Applied Microbiology, Biodiversity Conservation, Biophysics, Biostatistics, Crystallography of macromolecules., education in biology, Marine & Freshwater Biology, Mathematical & Computational Biology, Mycology, Nanoscience & Nanotechnology, Parasitology, Paleobiology, Astrobiology; Physiology, biopolymers, Soil biology, and Interdisciplinary Applications in biology.


The Open Biology Journal, a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and freely available to researchers worldwide.


Recent Articles

Epigenetics, Maternal Diet and Metabolic Programming

Karina Ramírez-Alarcón, Ángela Sánchez-Agurto, Liliana Lamperti, Miquel Martorell

Background:

The maternal environment influences embryonic and fetal life. Nutritional deficits or excesses alter the trajectory of fetus/offspring’s development. The concept of “developmental programming” and “developmental origins of health and disease” consists of the idea that maternal diet may remodel the genome and lead to epigenetic changes. These changes are induced during early life, permanently altering the phenotype in the posterior adult stage, favoring the development of metabolic diseases such as obesity, dyslipidemia, hypertension, hyperinsulinemia, and metabolic syndrome. In this review, it is aimed to overview epigenetics, maternal diet and metabolic programming factors and determine which of these might affect future generations.

Scope and Approach:

Nutrients interfere with the epigenome by influencing the supply and use of methyl groups through DNA transmethylation and demethylation mechanisms. They also influence the remodeling of chromatin and arginine or lysine residues at the N-terminal tails of histone, thus altering miRNA expression. Fats, proteins, B vitamins and folates act as important cofactors in methylation processes. The metabolism of carbon in the methyl groups of choline, folic acid and methionine to S-Adenosyl Methionine (SAM), acts as methyl donors to methyl DNA, RNA, and proteins. B-complex vitamins are important since they act as coenzymes during this process.

Key Findings and Conclusion:

Nutrients, during pregnancy, potentially influence susceptibility to diseases in adulthood. Additionally, the deficit or excess of nutrients alter the epigenetic machinery, affecting genes and influencing the genome of the offspring and therefore, predisposing the development of chronic diseases in adults.


December 13, 2019
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Editor's Choice

Safety of Using Diapers Containing Copper Oxide in Chronic Care Elderly Patients

Weinberg I, Lazary A, Jefidoff A, Vatine J-J, Borkow G, Ohana N

Copper has very potent antibacterial, antifungal, antiviral and acaricidal properties. Recently the use of copper alloys in hospital wards has been shown to reduce bioburden and nosocomial infection rates. We hypothesized that the use of copper oxide in textiles and other products that are in close contact with the patients may significantly reduce bioburden in clinical settings and consequently reduce the risk of nosocomial infections. In order to test this hypothesis we intend to conduct a trial in which we will examine if the nosocomial infection rates in a chronic care ward will be reduced when all the textile products will include copper oxide. The risk of adverse reactions due to dermal contact with copper are considered extremely low and medical devices containing copper, such as intrauterine devices and dental amalgams, are safely used for decades. Textile products containing copper oxide are being sold worldwide for several years and not even one adverse reaction was noted. However, in spite of all the above, and in preparation to the clinical trial we intend to conduct in a chronic care ward (long-term care facility), we conducted this preliminary study in which we examined the safety of using copper oxide impregnated diapers in 16 chronic care patients that used the diapers for 6 consecutive months. Importantly, not even one adverse reaction was recorded during the whole trial, indicating the high safety of the diapers. Therefore, this study allows us to examine the efficacy of textiles containing copper oxide in reducing nosocomial infections in larger populations, including in frail chronic care patients.


February 22, 2013
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