RESEARCH ARTICLE


Protein Aggregation in the Cell Nucleus: Structure, Function and Topology



Anna von Mikecz*
Institut für umweltmedizinische Forschung (IUF) at Heinrich-Heine-University Düsseldorf, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 197
Abstract HTML Views: 336
PDF Downloads: 221
Total Views/Downloads: 754
Unique Statistics:

Full-Text HTML Views: 140
Abstract HTML Views: 254
PDF Downloads: 175
Total Views/Downloads: 569



© 2009 Anna von Mikecz

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Institut fuer umweltmedizinische Forschung (IUF) at Heinrich-Heine-University Düsseldorf, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany; Tel: ++49-211-3389-358; E-mail: mikecz@tec-source.de; Web: www.tec-source.de/mikecz


Abstract

The nucleus represents a cellular control unit that regulates all events concerning the storage and processing of DNA and RNA. It is organized by highly crowded, dynamic assemblies of proteins and nucleic acids in molecular machines, ribonucleoprotein complexes, clusters of ongoing nuclear processes, nuclear bodies, and chromatin. This review discusses the occurrence of nuclear protein aggregation with special emphasis on the functional architecture of the nucleus, and quality control by the ubiquitin-proteasome system.

Keywords: Amyloid, gene expression, Huntington's disease, neurodegeneration, nucleus, polyglutamine, protein aggregation, trinucleotide repeat, ubiquitin-proteasome system.