Protein Aggregation in the Cell Nucleus: Structure, Function and Topology
Anna von Mikecz*
Identifiers and Pagination:Year: 2009
First Page: 193
Last Page: 199
Publisher Id: TOBIOJ-2-193
Article History:Received Date: 10/04/2009
Revision Received Date: 04/06/2009
Acceptance Date: 05/06/2009
Electronic publication date: 31/12/2009
Collection year: 2009
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The nucleus represents a cellular control unit that regulates all events concerning the storage and processing of DNA and RNA. It is organized by highly crowded, dynamic assemblies of proteins and nucleic acids in molecular machines, ribonucleoprotein complexes, clusters of ongoing nuclear processes, nuclear bodies, and chromatin. This review discusses the occurrence of nuclear protein aggregation with special emphasis on the functional architecture of the nucleus, and quality control by the ubiquitin-proteasome system.