RESEARCH ARTICLE


The Tightly Regulated and Compartmentalised Import, Sorting and Folding of Mitochondrial Proteins



Laura Cassina, Giorgio Casari*
Neurogenomics Unit, Center for Genomics, Bioinformatics and Biostatistics, San Raffaele Scientific Institute and San Raffaele University, Milan, Italy


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 241
Abstract HTML Views: 280
PDF Downloads: 135
Total Views/Downloads: 656
Unique Statistics:

Full-Text HTML Views: 178
Abstract HTML Views: 220
PDF Downloads: 111
Total Views/Downloads: 509



© 2009 Cassina and Casari

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the School of Medicine, San Raffaele University and San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy; Tel: +39 02 431; E-mail: casari.giorgio@hsr.it


Abstract

Mitochondria are eukaryotic intracellular organelles that still bear the signatures of their prokaryotic ancestor and require nuclear assistance. They generously dispense energy to cells, but are also involved in several biosynthetic processes, as well as in cell signalling pathways and programmed cell death.

Mitochondria are partitioned into four intra-organelle compartments: the outer membrane, the inner membrane, the intermembrane space and the matrix. Each compartment contains a unique set of proteins and a personalised system for guaranteeing protein homeostasis.

What follows is a survey of the function and topology of the multiple systems that operate the concerted action of protein sorting and folding in the four mitochondrial compartments.

Keywords: Mitochondrial proteins, mitochondrial proteins, folding, mitochondrial compartments, mitochondrial protein sorting.