Cation Channels in Erythrocytes - Historical and Future Perspective
Identifiers and Pagination:Year: 2011
First Page: 27
Last Page: 34
Publisher Id: TOBIOJ-4-27
Article History:Received Date: 15/12/2009
Revision Received Date: 04/07/2010
Acceptance Date: 15/07/2010
Electronic publication date: 31/1/2011
Collection year: 2011
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Compared to ion pumps and carriers, ion channels have been quite late recognised as individual transport identities in red blood cells. Here the transition from cell population based flux experiments to single cell based patchclamp investigations are described in detail. The present knowledge of cation channels in red blood cells from their molecular identity to their electrophysiological properties are summarised. Tendencies and novel concepts for future research concerning ion-transport across the red blood cell membrane are discussed.